IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy

IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy

Abstract Background Glioblastoma (GBM) brain tumors lacking IDH1 mutations (IDHwt) have the worst prognosis of all brain neoplasms. Patients receive surgery and chemoradiotherapy but tumors almost always fatally recur. Results Using RNA sequencing data from 107 pairs of pre- and post-standard treatm...

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Main Authors: Georgette Tanner, Rhiannon Barrow, Shoaib Ajaib, Muna Al-Jabri, Nazia Ahmed, Steven Pollock, Martina Finetti, Nora Rippaus, Alexander F. Bruns, Khaja Syed, James A. Poulter, Laura Matthews, Thomas Hughes, Erica Wilson, Colin Johnson, Frederick S. Varn, Anke Brüning-Richardson, Catherine Hogg, Alastair Droop, Arief Gusnanto, Matthew A. Care, Luisa Cutillo, David R. Westhead, Susan C. Short, Michael D. Jenkinson, Andrew Brodbelt, Aruna Chakrabarty, Azzam Ismail, Roel G. W. Verhaak, Lucy F. Stead
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Genome Biology
Online Access:https://doi.org/10.1186/s13059-024-03172-3

Internet

https://doi.org/10.1186/s13059-024-03172-3

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