Sanguinarine, Isolated From Macleaya cordata, Exhibits Potent Antifungal Efficacy Against Candida albicans Through Inhibiting Ergosterol Synthesis

Sanguinarine, Isolated From Macleaya cordata, Exhibits Potent Antifungal Efficacy Against Candida albicans Through Inhibiting Ergosterol Synthesis

In recent decades, infections caused by the opportunistic fungus Candida albicans have increased, especially in patients with immunodeficiency. In this study, we investigated the mechanism of action of sanguinarine (SAN) against C. albicans both in vitro and in vivo. SAN exhibited antifungal activit...

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Bibliographic Details
Main Authors: Ziwei Hu, Hao Hu, Zhili Hu, Xiaojun Zhong, Yifu Guan, Yunshi Zhao, Lu Wang, Liang Ye, Liliang Ming, Muhammad Shahid Riaz Rajoka, Zhendan He, Yan Wang, Xun Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Microbiology
Subjects:
sanguinarine
antifungal
C. albicans
ergosterol
mechanism
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.908461/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.908461/full

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