Interleukin-6 inhibition of hERG underlies risk for acquired long QT in cardiac and systemic inflammation.

Interleukin-6 inhibition of hERG underlies risk for acquired long QT in cardiac and systemic inflammation.

Increased proinflammatory interleukin-6 (IL-6) levels are associated with acquired long QT-syndrome (LQTS) in patients with systemic inflammation, leading to higher risks for life-threatening polymorphic ventricular tachycardia such as Torsades de Pointes. However, the functional and molecular mecha...

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Main Authors: Ademuyiwa S Aromolaran, Ujala Srivastava, Alessandra Alí, Mohamed Chahine, Deana Lazaro, Nabil El-Sherif, Pier Leopoldo Capecchi, Franco Laghi-Pasini, Pietro Enea Lazzerini, Mohamed Boutjdir
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0208321

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https://doi.org/10.1371/journal.pone.0208321

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