Design, Synthesis and Pharmacological Evaluation of Novel Hsp90N‐terminal Inhibitors Without Induction of Heat Shock Response

Design, Synthesis and Pharmacological Evaluation of Novel Hsp90N‐terminal Inhibitors Without Induction of Heat Shock Response

Abstract Heat shock protein 90 (Hsp90) is a potential oncogenic target. However, Hsp90 inhibitors in clinical trial induce heat shock response, resulting in drug resistance and inefficiency. In this study, we designed and synthesized a series of novel triazine derivatives (A1‐26, B1‐13, C1‐23) as Hs...

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Bibliographic Details
Main Authors: Dr. Peng Liu, Dr. Xiangling Chen, Dr. Jianming Zhu, Dr. Bo Li, Dr. Zhaoqiang Chen, Dr. Guimin Wang, Dr. Haiguo Sun, Dr. Zhijian Xu, Dr. Zhixin Zhao, Dr. Chen Zhou, Dr. Chengying Xie, Prof. Liguang Lou, Prof. Weiliang Zhu
Format: Article
Language:English
Published: Wiley-VCH 2019-03-01
Series:ChemistryOpen
Subjects:
autophagy
Hsp72
Hsp90 inhibitor
triazines
antitumor activity
Online Access:https://doi.org/10.1002/open.201900055

Internet

https://doi.org/10.1002/open.201900055

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