The Small Molecule PPARγ Agonist GL516 Induces Feeding-Stimulatory Effects in Hypothalamus Cells Hypo-E22 and Isolated Hypothalami

The Small Molecule PPARγ Agonist GL516 Induces Feeding-Stimulatory Effects in Hypothalamus Cells Hypo-E22 and Isolated Hypothalami

PPARγ agonists are implicated in the regulation of diabetes and metabolic syndrome and have therapeutic potential in brain disorders. PPARγ modulates appetite through its central effects, especially on the hypothalamic arcuate nucleus (ARC). Previous studies demonstrated that the small molecule GL51...

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Bibliographic Details
Main Authors: Annalisa Chiavaroli, Viviana di Giacomo, Barbara De Filippis, Amelia Cataldi, Claudio Ferrante, Letizia Giampietro
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Molecules
Subjects:
PPARγ agonists
fibrates
neuroprotection
hypothalamus
small molecules
neuropeptides
Online Access:https://www.mdpi.com/1420-3049/27/15/4882

Internet

https://www.mdpi.com/1420-3049/27/15/4882

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