Chili pepper extracts, capsaicin, and dihydrocapsaicin as potential anticancer agents targeting topoisomerases

Chili pepper extracts, capsaicin, and dihydrocapsaicin as potential anticancer agents targeting topoisomerases

Abstract DNA topoisomerases regulate conformational changes in DNA topology during normal cell growth, such as replication, transcription, recombination, and repair, and may be targeted for anticancer drugs. A DNA topology assay was used to investigate DNA-damaging/protective activities of extracts...

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Bibliographic Details
Main Authors: Terézia Hudáková, Martina Šemeláková, Peter Očenáš, Mária Kožurková, Kristína Krochtová, Simona Sovová, Zuzana Tóthová, Zuzana Guľášová, Peter Popelka, Peter Solár
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Chili pepper extract
Capsaicin
Dihydrocapsaicin
Topoisomerases inhibition
Online Access:https://doi.org/10.1186/s12906-024-04394-5

Internet

https://doi.org/10.1186/s12906-024-04394-5

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