Reversible adaptive plasticity: A mechanism for neuroblastoma cell heterogeneity and chemo-resistance

Reversible adaptive plasticity: A mechanism for neuroblastoma cell heterogeneity and chemo-resistance

We describe a novel form of tumor cell plasticity characterized by reversible adaptive plasticity in murine and human neuroblastoma. Two cellular phenotypes were defined by their ability to exhibit adhered, anchorage dependent (AD) or sphere forming, anchorage independent (AI) growth. The tumor cel...

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Bibliographic Details
Main Authors: Lina eChakrabarti, Thamara eAbou-Antoun, Stanislav eVukmanovic, Anthony D Sandler
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Oncology
Subjects:
Neuroblastoma
Phenotypic switching
tumor cell adaptation
tumor cell plasticity
tumor heterogeneity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00082/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00082/full

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