Phlorotannins from <i>Ecklonia cava</i> Attenuates Palmitate-Induced Endoplasmic Reticulum Stress and Leptin Resistance in Hypothalamic Neurons

Phlorotannins from <i>Ecklonia cava</i> Attenuates Palmitate-Induced Endoplasmic Reticulum Stress and Leptin Resistance in Hypothalamic Neurons

Leptin resistance in the hypothalamus has an essential role in obesity. Saturated fatty acids such as palmitate bind to Toll-like receptor 4 (TLR4) and lead to endoplasmic reticulum (ER) stress and leptin resistance. In this study, we evaluated whether extracts of <i>Ecklonia cava</i> wo...

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Bibliographic Details
Main Authors: Seyeon Oh, Myeongjoo Son, Junwon Choi, Chang Hu Choi, Kook Yang Park, Kuk Hui Son, Kyunghee Byun
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Marine Drugs
Subjects:
obesity
<i>ecklonia cava</i>
phlorotannins
hypothalamic neurons
microglia
toll-like receptor 4
endoplasmic reticulum stress
leptin resistance
Online Access:https://www.mdpi.com/1660-3397/17/10/570

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https://www.mdpi.com/1660-3397/17/10/570

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