Leishmania major Strain-Dependent Macrophage Activation Contributes to Pathogenicity in the Absence of Lymphocytes

Leishmania major Strain-Dependent Macrophage Activation Contributes to Pathogenicity in the Absence of Lymphocytes

ABSTRACT Infection of C57BL/6 wild-type mice with Leishmania major 5-ASKH or Friedlin strains results in relatively similar pathogenicity with self-healing lesions within weeks. Parasite clearance depends on nitric oxide production by activated macrophages in response to cytokines produced mainly by...

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Bibliographic Details
Main Authors: Jalal Alshaweesh, Risa Nakamura, Yuka Tanaka, Mizuki Hayashishita, Abu Musa, Mihoko Kikuchi, Daniel Ken Inaoka, Shinjiro Hamano
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:Microbiology Spectrum
Subjects:
Leishmania major
cutaneous leishmaniasis
lymphocyte-independent pathology
strain-dependent virulence
neutrophilic inflammation
macrophage activation
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01126-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.01126-22

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