Solid-Phase Synthesis of Phosphorothioate/Phosphonothioate and Phosphoramidate/Phosphonamidate Oligonucleotides

Solid-Phase Synthesis of Phosphorothioate/Phosphonothioate and Phosphoramidate/Phosphonamidate Oligonucleotides

We have developed a robust solid-phase protocol which allowed the synthesis of chimeric oligonucleotides modified with phosphodiester and <i>O</i>-methylphosphonate linkages as well as their <i>P-S</i> and <i>P-N</i> variants. The novel <i>O</i>-methyl...

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Bibliographic Details
Main Authors: Ondřej Kostov, Radek Liboska, Ondřej Páv, Pavel Novák, Ivan Rosenberg
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
<i>H</i>-phosphinate
<i>H</i>-phosphonate
phosphoramidite
oligonucleotide
phosphonate
phosphorothioate
phosphonothioate
phosphoramidate
phosphonamidate
Online Access:https://www.mdpi.com/1420-3049/24/10/1872

Internet

https://www.mdpi.com/1420-3049/24/10/1872

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