TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction

TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction

TLR3 activates a potent immune response by binding to dsRNA. Here the authors report cryo-EM analyses to show that TLR3 dimers laterally form a higher multimeric complex along dsRNA, providing the basis for cooperative binding and efficient signal transduction.

Bibliographic Details
Main Authors: Kentaro Sakaniwa, Akiko Fujimura, Takuma Shibata, Hideki Shigematsu, Toru Ekimoto, Masaki Yamamoto, Mitsunori Ikeguchi, Kensuke Miyake, Umeharu Ohto, Toshiyuki Shimizu
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-35844-2

Internet

https://doi.org/10.1038/s41467-023-35844-2

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