TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction
TLR3 activates a potent immune response by binding to dsRNA. Here the authors report cryo-EM analyses to show that TLR3 dimers laterally form a higher multimeric complex along dsRNA, providing the basis for cooperative binding and efficient signal transduction.
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-01-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-35844-2 |
Summary: | TLR3 activates a potent immune response by binding to dsRNA. Here the authors report cryo-EM analyses to show that TLR3 dimers laterally form a higher multimeric complex along dsRNA, providing the basis for cooperative binding and efficient signal transduction. |
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ISSN: | 2041-1723 |