TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction
TLR3 activates a potent immune response by binding to dsRNA. Here the authors report cryo-EM analyses to show that TLR3 dimers laterally form a higher multimeric complex along dsRNA, providing the basis for cooperative binding and efficient signal transduction.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-35844-2 |
| _version_ | 1797952395901140992 |
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| author | Kentaro Sakaniwa Akiko Fujimura Takuma Shibata Hideki Shigematsu Toru Ekimoto Masaki Yamamoto Mitsunori Ikeguchi Kensuke Miyake Umeharu Ohto Toshiyuki Shimizu |
| author_facet | Kentaro Sakaniwa Akiko Fujimura Takuma Shibata Hideki Shigematsu Toru Ekimoto Masaki Yamamoto Mitsunori Ikeguchi Kensuke Miyake Umeharu Ohto Toshiyuki Shimizu |
| author_sort | Kentaro Sakaniwa |
| collection | DOAJ |
| description | TLR3 activates a potent immune response by binding to dsRNA. Here the authors report cryo-EM analyses to show that TLR3 dimers laterally form a higher multimeric complex along dsRNA, providing the basis for cooperative binding and efficient signal transduction. |
| first_indexed | 2024-04-10T22:46:43Z |
| format | Article |
| id | doaj.art-191eb9ffbbaf4c64a5feaddd969568ae |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T22:46:43Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-191eb9ffbbaf4c64a5feaddd969568ae2023-01-15T12:16:13ZengNature PortfolioNature Communications2041-17232023-01-011411810.1038/s41467-023-35844-2TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transductionKentaro Sakaniwa0Akiko Fujimura1Takuma Shibata2Hideki Shigematsu3Toru Ekimoto4Masaki Yamamoto5Mitsunori Ikeguchi6Kensuke Miyake7Umeharu Ohto8Toshiyuki Shimizu9Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 HongoGraduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 HongoDivision of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1 ShirokanedaiRIKEN SPring-8 Center, 1-1-1 KoutoComputational Life Science Laboratory, Graduate School of Medical Life Science, Yokohama City University, 1-7-29, Suehiro-cho, Tsurumi-kuRIKEN SPring-8 Center, 1-1-1 KoutoComputational Life Science Laboratory, Graduate School of Medical Life Science, Yokohama City University, 1-7-29, Suehiro-cho, Tsurumi-kuDivision of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1 ShirokanedaiGraduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 HongoGraduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 HongoTLR3 activates a potent immune response by binding to dsRNA. Here the authors report cryo-EM analyses to show that TLR3 dimers laterally form a higher multimeric complex along dsRNA, providing the basis for cooperative binding and efficient signal transduction.https://doi.org/10.1038/s41467-023-35844-2 |
| spellingShingle | Kentaro Sakaniwa Akiko Fujimura Takuma Shibata Hideki Shigematsu Toru Ekimoto Masaki Yamamoto Mitsunori Ikeguchi Kensuke Miyake Umeharu Ohto Toshiyuki Shimizu TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction Nature Communications |
| title | TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction |
| title_full | TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction |
| title_fullStr | TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction |
| title_full_unstemmed | TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction |
| title_short | TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction |
| title_sort | tlr3 forms a laterally aligned multimeric complex along double stranded rna for efficient signal transduction |
| url | https://doi.org/10.1038/s41467-023-35844-2 |
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