Deletion of UCP1 in Tg2576 Mice Increases Body Temperature and Exacerbates Alzheimer’s Disease-Related Pathologies

Deletion of UCP1 in Tg2576 Mice Increases Body Temperature and Exacerbates Alzheimer’s Disease-Related Pathologies

We previously demonstrated that the Alzheimer’s disease (AD)-like model mice, Tg2576, housed at a high ambient temperature of 30 °C for 13 months, exhibited increased body temperature, which increased amyloid-β (Aβ) levels and tau stability, leading to tau phosphorylation and ultimately inducing mem...

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Bibliographic Details
Main Authors: Cha-Gyun Jung, Hitoshi Yamashita, Reiko Kato, Chunyu Zhou, Hiroaki Matsushita, Tamaki Takeuchi, Mona Abdelhamid, Yuxin Chen, Makoto Michikawa
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
uncoupling protein 1
high body temperature
Aβ generation
BACE1
NEP
Online Access:https://www.mdpi.com/1422-0067/24/3/2741

Internet

https://www.mdpi.com/1422-0067/24/3/2741

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