Systematic investigation of the underlying mechanisms of GLP-1 receptor agonists to prevent myocardial infarction in patients with type 2 diabetes mellitus using network pharmacology

Systematic investigation of the underlying mechanisms of GLP-1 receptor agonists to prevent myocardial infarction in patients with type 2 diabetes mellitus using network pharmacology

Background: Several clinical trials have demonstrated that glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) reduce the incidence of non-fatal myocardial infarction (MI) in patients with type 2 diabetes mellitus (T2DM). However, the underlying mechanism remains unclear. In this study, we...

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Bibliographic Details
Main Authors: Guorong Deng, Jiajia Ren, Ruohan Li, Minjie Li, Xuting Jin, Jiamei Li, Jueheng Liu, Ya Gao, Jingjing Zhang, Xiaochuang Wang, Gang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Pharmacology
Subjects:
GLP-1 receptor agonists
type 2 diabetes mellitus
myocardial infarction
network pharmacology
atheromatous plaque
myocardial remodeling
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1125753/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1125753/full

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