An IL‐12‐Based Nanocytokine Safely Potentiates Anticancer Immunity through Spatiotemporal Control of Inflammation to Eradicate Advanced Cold Tumors

An IL‐12‐Based Nanocytokine Safely Potentiates Anticancer Immunity through Spatiotemporal Control of Inflammation to Eradicate Advanced Cold Tumors

Abstract Treatment of immunologically cold tumors is a major challenge for immune checkpoint inhibitors (ICIs). Interleukin 12 (IL‐12) can invigorate ICIs against cold tumors by establishing a robust antitumor immunity. However, its toxicity and systemic induction of counteracting immunosuppressive...

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Bibliographic Details
Main Authors: Pengwen Chen, Wenqian Yang, Koji Nagaoka, George Lo Huang, Takuya Miyazaki, Taehun Hong, Shangwei Li, Kazunori Igarashi, Kazuyoshi Takeda, Kazuhiro Kakimi, Kazunori Kataoka, Horacio Cabral
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Advanced Science
Subjects:
breast cancer
cytokine
immune checkpoint inhibitor
immunotherapy
interleukin‐12
metastatic tumor
Online Access:https://doi.org/10.1002/advs.202205139

Internet

https://doi.org/10.1002/advs.202205139

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