Co-occurrence of JAK2-V617 F mutation and BCR::ABL1 translocation in chronic myeloproliferative neoplasms: a potentially confounding genetic combination

Co-occurrence of JAK2-V617 F mutation and BCR::ABL1 translocation in chronic myeloproliferative neoplasms: a potentially confounding genetic combination

Myeloproliferative neoplasms (MPNs) are classified into Philadelphia (Ph) chromosome–positive chronic myeloid leukemia (CML) and Ph-negative MPNs. BCR::ABL1 translocation is the key genetic event of CML, whereas JAK2/MPL/CALR mutations are molecular aberrations of Ph-negative MPNs. Despite initially...

Полное описание

Библиографические подробности
Главные авторы: Magda Zanelli, Alessandra Bisagni, Francesca Sanguedolce, Giuseppe Broggi, Valentina Fragliasso, Maurizio Zizzo, Andrea Palicelli, Giovanni Martino, Camilla Cresta, Cecilia Caprera, Matteo Corsi, Pietro Gentile, Fabrizio Gozzi, Domenico Trombetta, Paola Parente, Rosario Caltabiano, Nektarios Koufopoulos, Luca Cimino, Alberto Cavazza, Giulio Fraternali Orcioni, Stefano Ascani
Формат: Статья
Язык:English
Опубликовано: Frontiers Media S.A. 2024-01-01
Серии:Frontiers in Oncology
Предметы:
BCR::ABL1
JAK2
chronic myeloid leukemia
myeloproliferative neoplasm
polycythemia vera
primary myelofibrosis
Online-ссылка:https://www.frontiersin.org/articles/10.3389/fonc.2023.1329298/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1329298/full

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