Inhibition of Cyclin-Dependent Kinases 8/19 Restricts Bacterial and Virus-Induced Inflammatory Responses in Monocytes

Inhibition of Cyclin-Dependent Kinases 8/19 Restricts Bacterial and Virus-Induced Inflammatory Responses in Monocytes

Hyperactivation of the immune system remains a dramatic, life-threatening complication of viral and bacterial infections, particularly during pneumonia. Therapeutic approaches to counteract local and systemic outbreaks of cytokine storm and to prevent tissue damage remain limited. Cyclin-dependent k...

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Bibliographic Details
Main Authors: Elena K. Kokinos, Sergey A. Tsymbal, Anastasia V. Galochkina, Svetlana A. Bezlepkina, Julia V. Nikolaeva, Sofia O. Vershinina, Anna A. Shtro, Victor V. Tatarskiy, Alexander A. Shtil, Eugenia V. Broude, Igor B. Roninson, Marina Dukhinova
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Viruses
Subjects:
inflammation
monocytes
influenza virus
lipopolysaccharide
CDK8/19
cytokines
Online Access:https://www.mdpi.com/1999-4915/15/6/1292

Internet

https://www.mdpi.com/1999-4915/15/6/1292

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