Discovery of a novel natural product inhibitor of Clostridioides difficile with potent activity in vitro and in vivo.

Clostridioides difficile infection is a global health threat and remains the primary cause of hospital-acquired infections worldwide. The burgeoning incidence and severity of infections coupled with high rates of recurrence have created an urgent need for novel therapeutics. Here, we report a novel...

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Bibliographic Details
Main Authors: Rusha Pal, Mohamed N Seleem
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0267859