The Regulatory T Cell Lineage Factor Foxp3 Regulates Gene Expression through Several Distinct Mechanisms Mostly Independent of Direct DNA Binding.

The Regulatory T Cell Lineage Factor Foxp3 Regulates Gene Expression through Several Distinct Mechanisms Mostly Independent of Direct DNA Binding.

The lineage factor Foxp3 is essential for the development and maintenance of regulatory T cells, but little is known about the mechanisms involved. Here, we demonstrate that an N-terminal proline-rich interaction region is crucial for Foxp3's function. Subdomains within this key region link Fox...

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Bibliographic Details
Main Authors: Xin Xie, Michael J T Stubbington, Jesper K Nissen, Kristian G Andersen, Daniel Hebenstreit, Sarah A Teichmann, Alexander G Betz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4480970?pdf=render

Internet

http://europepmc.org/articles/PMC4480970?pdf=render

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