Enzyme Responsive Vaginal Microbicide Gels Containing Maraviroc and Tenofovir Microspheres Designed for Acid Phosphatase-Triggered Release for Pre-Exposure Prophylaxis of HIV-1: A Comparative Analysis of a Bigel and Thermosensitive Gel

Enzyme Responsive Vaginal Microbicide Gels Containing Maraviroc and Tenofovir Microspheres Designed for Acid Phosphatase-Triggered Release for Pre-Exposure Prophylaxis of HIV-1: A Comparative Analysis of a Bigel and Thermosensitive Gel

The challenges encountered with conventional microbicide gels has necessitated the quest for alternative options. This study aimed to formulate and evaluate a bigel and thermosensitive gel, designed to combat the challenges of leakage and short-residence time in the vagina. Ionic-gelation technique...

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Bibliographic Details
Main Authors: Sabdat Ozichu Ekama, Margaret O. Ilomuanya, Chukwuemeka Paul Azubuike, James Babatunde Ayorinde, Oliver Chukwujekwu Ezechi, Cecilia Ihuoma Igwilo, Babatunde Lawal Salako
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Gels
Subjects:
HIV prevention
pre-exposure prophylaxis
HIV/AIDS
vaginal gels microbicides
acid phosphatase
microparticles
Online Access:https://www.mdpi.com/2310-2861/8/1/15

Internet

https://www.mdpi.com/2310-2861/8/1/15

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