Tourniquet‐induced lower limb ischemia/reperfusion reduces mitochondrial function by decreasing mitochondrial biogenesis in acute kidney injury in mice

Tourniquet‐induced lower limb ischemia/reperfusion reduces mitochondrial function by decreasing mitochondrial biogenesis in acute kidney injury in mice

Abstract The mechanisms by which lower limb ischemia/reperfusion induces acute kidney injury (AKI) remain largely uncharacterized. We hypothesized that tourniquet‐induced lower limb ischemia/reperfusion (TILLIR) would inhibit mitochondrial function in the renal cortex. We used a murine model to show...

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Bibliographic Details
Main Authors: Balamurugan Packialakshmi, Ian J. Stewart, David M. Burmeister, Yuanyi Feng, Dennis P. McDaniel, Kevin K. Chung, Xiaoming Zhou
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:Physiological Reports
Subjects:
autophagy
ischemia
mitochondrial complex
mitochondrial oxidative stress
mitophagy
Online Access:https://doi.org/10.14814/phy2.15181

Internet

https://doi.org/10.14814/phy2.15181

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