Antitumor effect of plant-produced anti-CTLA-4 monoclonal antibody in a murine model of colon cancer

Antitumor effect of plant-produced anti-CTLA-4 monoclonal antibody in a murine model of colon cancer

Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) is an immune checkpoint regulator exclusively expressed on T cells that obstructs the cell’s effector functions. Ipilimumab (Yervoy®), a CTLA-4 blocking antibody, emerged as a notable breakthrough in modern cancer treatment, showing upfront clinic...

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Bibliographic Details
Main Authors: Christine Joy I. Bulaon, Narach Khorattanakulchai, Kaewta Rattanapisit, Hongyan Sun, Nuttapat Pisuttinusart, Richard Strasser, Shiho Tanaka, Patrick Soon-Shiong, Waranyoo Phoolcharoen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Plant Science
Subjects:
cytotoxic T lymphocyte-associated protein 4
2C8
anti-CTLA-4 antibody
Nicotiana benthamiana
cancer immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fpls.2023.1149455/full

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https://www.frontiersin.org/articles/10.3389/fpls.2023.1149455/full

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