The histone methyltransferase WHSC1 is regulated by EZH2 and is important for ovarian clear cell carcinoma cell proliferation

The histone methyltransferase WHSC1 is regulated by EZH2 and is important for ovarian clear cell carcinoma cell proliferation

Abstract Background Wolf-Hirschhorn syndrome candidate gene-1 (WHSC1), a histone methyltransferase, has been found to be upregulated and its expression to be correlated with expression of enhancer of zeste homolog 2 (EZH2) in several cancers. In this study, we evaluated the role of WHSC1 and its the...

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Main Authors: Machiko Kojima, Kenbun Sone, Katsutoshi Oda, Ryuji Hamamoto, Syuzo Kaneko, Shinya Oki, Asako Kukita, Hidenori Machino, Harunori Honjoh, Yoshiko Kawata, Tomoko Kashiyama, Kayo Asada, Michihiro Tanikawa, Mayuyo Mori-Uchino, Tetsushi Tsuruga, Kazunori Nagasaka, Yoko Matsumoto, Osamu Wada-Hiraike, Yutaka Osuga, Tomoyuki Fujii
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Cancer
Subjects:
Histone methyltransferase, Wolf-Hirschhorn syndrome candidate gene-1
Enhancer of zeste homolog 2
Ovarian clear cell carcinoma
Epigenetic modifier
EZH2 selective inhibitor, H3K36 dimethylation, cell proliferation
Online Access:http://link.springer.com/article/10.1186/s12885-019-5638-9

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http://link.springer.com/article/10.1186/s12885-019-5638-9

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