Using quantitative single molecule localization microscopy to optimize multivalent HER2-targeting ligands

Using quantitative single molecule localization microscopy to optimize multivalent HER2-targeting ligands

IntroductionThe progression-free survival of patients with HER2-positive metastatic breast cancer is significantly extended by a combination of two monoclonal antibodies, trastuzumab and pertuzumab, which target independent epitopes of the extracellular domain of HER2. The improved efficacy of the c...

Full description

Bibliographic Details
Main Authors: Devin L. Wakefield, Ottavia Golfetto, Raphael Jorand, Sunetra Biswas, Kassondra Meyer, Kendra N. Avery, Cindy Zer, Eliedonna E. Cacao, Steven J. Tobin, Ian J. Talisman, John C. Williams, Tijana Jovanovic-Talisman
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Medicine
Subjects:
HER2
meditope
valency
single molecule localization microscopy
trastuzumab
pertuzumab
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1064242/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2023.1064242/full

Similar Items