Dihydrolipoamide dehydrogenase regulates cystine deprivation-induced ferroptosis in head and neck cancer

Ferroptosis is a new form of regulated cell death driven by iron-dependent lipid peroxidation. Glutaminolysis and tricarboxylic acid cycle are involved in ferroptosis, but the underlying metabolic process remains unclear. We examined the role of dihydrolipoamide dehydrogenase (DLD) in ferroptosis in...

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Bibliographic Details
Main Authors: Daiha Shin, Jaewang Lee, Ji Hyeon You, Doyeon Kim, Jong-Lyel Roh
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231719314351