Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires FcγRIIB and virus-antibody complex with bivalent interaction

Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires FcγRIIB and virus-antibody complex with bivalent interaction

By distinguishing between two types of neutralizing antibodies that either exhibit or lack antibody-dependent enhancement (ADE) activity, FcγRIIB and bivalent binding are shown to be required for ADE in SARS-CoV-2 infection.

Bibliographic Details
Main Authors: Shuang Wang, Junchao Wang, Xiaojuan Yu, Wen Jiang, Shuo Chen, Rongjuan Wang, Mingzhu Wang, Shasha Jiao, Yingying Yang, Wenbo Wang, Huilin Chen, Ben Chen, Chunying Gu, Chuang Liu, An Wang, Min Wang, Gang Li, Cuicui Guo, Datao Liu, Jinchao Zhang, Min Zhang, Lan Wang, Xun Gui
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03207-0

Internet

https://doi.org/10.1038/s42003-022-03207-0

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