Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires FcγRIIB and virus-antibody complex with bivalent interaction
By distinguishing between two types of neutralizing antibodies that either exhibit or lack antibody-dependent enhancement (ADE) activity, FcγRIIB and bivalent binding are shown to be required for ADE in SARS-CoV-2 infection.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-03-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03207-0 |
| _version_ | 1811332123979677696 |
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| author | Shuang Wang Junchao Wang Xiaojuan Yu Wen Jiang Shuo Chen Rongjuan Wang Mingzhu Wang Shasha Jiao Yingying Yang Wenbo Wang Huilin Chen Ben Chen Chunying Gu Chuang Liu An Wang Min Wang Gang Li Cuicui Guo Datao Liu Jinchao Zhang Min Zhang Lan Wang Xun Gui |
| author_facet | Shuang Wang Junchao Wang Xiaojuan Yu Wen Jiang Shuo Chen Rongjuan Wang Mingzhu Wang Shasha Jiao Yingying Yang Wenbo Wang Huilin Chen Ben Chen Chunying Gu Chuang Liu An Wang Min Wang Gang Li Cuicui Guo Datao Liu Jinchao Zhang Min Zhang Lan Wang Xun Gui |
| author_sort | Shuang Wang |
| collection | DOAJ |
| description | By distinguishing between two types of neutralizing antibodies that either exhibit or lack antibody-dependent enhancement (ADE) activity, FcγRIIB and bivalent binding are shown to be required for ADE in SARS-CoV-2 infection. |
| first_indexed | 2024-04-13T16:32:06Z |
| format | Article |
| id | doaj.art-1931eb3ad9a74801a89ebf34511f0976 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-13T16:32:06Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-1931eb3ad9a74801a89ebf34511f09762022-12-22T02:39:32ZengNature PortfolioCommunications Biology2399-36422022-03-01511910.1038/s42003-022-03207-0Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires FcγRIIB and virus-antibody complex with bivalent interactionShuang Wang0Junchao Wang1Xiaojuan Yu2Wen Jiang3Shuo Chen4Rongjuan Wang5Mingzhu Wang6Shasha Jiao7Yingying Yang8Wenbo Wang9Huilin Chen10Ben Chen11Chunying Gu12Chuang Liu13An Wang14Min Wang15Gang Li16Cuicui Guo17Datao Liu18Jinchao Zhang19Min Zhang20Lan Wang21Xun Gui22Mabwell (Shanghai) Bioscience Co., LtdSchool of Life Sciences, Anhui UniversityKey Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug ControlMabwell (Shanghai) Bioscience Co., LtdLudwig Cancer Research, Nuffield Department of Medicine, University of OxfordMabwell (Shanghai) Bioscience Co., LtdSchool of Life Sciences, Anhui UniversityMabwell (Shanghai) Bioscience Co., LtdMabwell (Shanghai) Bioscience Co., LtdKey Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug ControlMabwell (Shanghai) Bioscience Co., LtdMabwell (Shanghai) Bioscience Co., LtdMabwell (Shanghai) Bioscience Co., LtdMabwell (Shanghai) Bioscience Co., LtdMabwell (Shanghai) Bioscience Co., LtdMabwell (Shanghai) Bioscience Co., LtdMabwell (Shanghai) Bioscience Co., LtdMabwell (Shanghai) Bioscience Co., LtdMabwell (Shanghai) Bioscience Co., LtdMabwell (Shanghai) Bioscience Co., LtdSchool of Life Sciences, Anhui UniversityKey Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug ControlMabwell (Shanghai) Bioscience Co., LtdBy distinguishing between two types of neutralizing antibodies that either exhibit or lack antibody-dependent enhancement (ADE) activity, FcγRIIB and bivalent binding are shown to be required for ADE in SARS-CoV-2 infection.https://doi.org/10.1038/s42003-022-03207-0 |
| spellingShingle | Shuang Wang Junchao Wang Xiaojuan Yu Wen Jiang Shuo Chen Rongjuan Wang Mingzhu Wang Shasha Jiao Yingying Yang Wenbo Wang Huilin Chen Ben Chen Chunying Gu Chuang Liu An Wang Min Wang Gang Li Cuicui Guo Datao Liu Jinchao Zhang Min Zhang Lan Wang Xun Gui Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires FcγRIIB and virus-antibody complex with bivalent interaction Communications Biology |
| title | Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires FcγRIIB and virus-antibody complex with bivalent interaction |
| title_full | Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires FcγRIIB and virus-antibody complex with bivalent interaction |
| title_fullStr | Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires FcγRIIB and virus-antibody complex with bivalent interaction |
| title_full_unstemmed | Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires FcγRIIB and virus-antibody complex with bivalent interaction |
| title_short | Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires FcγRIIB and virus-antibody complex with bivalent interaction |
| title_sort | antibody dependent enhancement ade of sars cov 2 pseudoviral infection requires fcγriib and virus antibody complex with bivalent interaction |
| url | https://doi.org/10.1038/s42003-022-03207-0 |
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