Thymoquinone Enhances Apoptosis of K562 Chronic Myeloid Leukemia Cells through Hypomethylation of <i>SHP-1</i> and Inhibition of JAK/STAT Signaling Pathway

Thymoquinone Enhances Apoptosis of K562 Chronic Myeloid Leukemia Cells through Hypomethylation of <i>SHP-1</i> and Inhibition of JAK/STAT Signaling Pathway

The epigenetic silencing of tumor suppressor genes (TSGs) is critical in the development of chronic myeloid leukemia (CML). <i>SHP-1</i> functions as a TSG and negatively regulates JAK/STAT signaling. Enhancement of <i>SHP-1</i> expression by demethylation provides molecular...

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Bibliographic Details
Main Authors: Futoon Abedrabbu Al-Rawashde, Ola M. Al-Sanabra, Moath Alqaraleh, Ahmad Q. Jaradat, Abdullah Saleh Al-Wajeeh, Muhammad Farid Johan, Wan Rohani Wan Taib, Imilia Ismail, Hamid Ali Nagi Al-Jamal
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Pharmaceuticals
Subjects:
thymoquinone
CML
hypomethylation
<i>SHP-1</i>
JAK/STAT
<i>DNMT1</i>
Online Access:https://www.mdpi.com/1424-8247/16/6/884

Internet

https://www.mdpi.com/1424-8247/16/6/884

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