Aptamer-Functionalized Drug Nanocarrier Improves Hepatocellular Carcinoma toward Normal by Targeting Neoplastic Hepatocytes

Aptamer-Functionalized Drug Nanocarrier Improves Hepatocellular Carcinoma toward Normal by Targeting Neoplastic Hepatocytes

Site-specific delivery of chemotherapeutics specifically to neoplastic hepatocytes without affecting normal hepatocytes should be a focus for potential therapeutic management of hepatocellular carcinoma (HCC). The aptamer TLS 9a with phosphorothioate backbone modifications (L5) has not been explored...

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Bibliographic Details
Main Authors: Samrat Chakraborty, Zewdu Yilma Dlie, Somdyuti Chakraborty, Somdatta Roy, Biswajit Mukherjee, Shila Elizabeth Besra, Saikat Dewanjee, Alankar Mukherjee, Probir Kumar Ojha, Vinay Kumar, Ramkrishna Sen
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
site-specific targeting
hepatocarcinogenesis
apoptosis
mitochondrial-dependent intrinsic pathway
molecular modeling
TAG-72
Online Access:http://www.sciencedirect.com/science/article/pii/S216225312030069X

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http://www.sciencedirect.com/science/article/pii/S216225312030069X

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