PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids

PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids

Objectives: Peroxisome proliferator-activated receptor γ coactivator 1 (PPARGCA1, PGC-1) transcriptional coactivators control gene programs important for nutrient metabolism. Islets of type 2 diabetic subjects have reduced PGC-1α expression and this is associated with decreased insulin secretion, ye...

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Bibliographic Details
Main Authors: Daniel Oropeza, Nathalie Jouvet, Khalil Bouyakdan, Gabrielle Perron, Lea-Jeanne Ringuette, Louis H. Philipson, Robert S. Kiss, Vincent Poitout, Thierry Alquier, Jennifer L. Estall
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Molecular Metabolism
Subjects:
Beta cell
PGC-1
Insulin secretion
Lipid metabolism
Mitochondria
Lipolysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815001453

Internet

http://www.sciencedirect.com/science/article/pii/S2212877815001453

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