Asymmetric Centriole Numbers at Spindle Poles Cause Chromosome Missegregation in Cancer

Asymmetric Centriole Numbers at Spindle Poles Cause Chromosome Missegregation in Cancer

Chromosomal instability is a hallmark of cancer and correlates with the presence of extra centrosomes, which originate from centriole overduplication. Overduplicated centrioles lead to the formation of centriole rosettes, which mature into supernumerary centrosomes in the subsequent cell cycle. Whil...

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Bibliographic Details
Main Authors: Marco R. Cosenza, Anna Cazzola, Annik Rossberg, Nicole L. Schieber, Gleb Konotop, Elena Bausch, Alla Slynko, Tim Holland-Letz, Marc S. Raab, Taronish Dubash, Hanno Glimm, Sven Poppelreuther, Christel Herold-Mende, Yannick Schwab, Alwin Krämer
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
chromosomal instability
centriole
centrosome
PLK4
STIL
mitosis
cancer
microtubule
merotely
chromosome missegregation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717310768

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http://www.sciencedirect.com/science/article/pii/S2211124717310768

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