Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors

Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors

Virus-based tumour vaccines offer many advantages compared to other antigen-delivering systems. They generate concerted innate and adaptive immune response, and robust CD8+ T cell responses. We engineered a non-replicating pseudotyped influenza virus (S-FLU) to deliver the well-known cancer testis a...

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Bibliographic Details
Main Authors: Matheswaran Kandasamy, Uzi Gileadi, Pramila Rijal, Tiong Kit Tan, Lian N Lee, Jili Chen, Gennaro Prota, Paul Klenerman, Alain Townsend, Vincenzo Cerundolo
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-01-01
Series:eLife
Subjects:
cancer vaccine
influenza virus
tumour metastasis
Online Access:https://elifesciences.org/articles/76414

Internet

https://elifesciences.org/articles/76414

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