Up-regulation of expression and lack of 5' CpG island hypermethylation of <it>p16 INK4a </it>in HPV-positive cervical carcinomas

Up-regulation of expression and lack of 5' CpG island hypermethylation of <it>p16 INK4a </it>in HPV-positive cervical carcinomas

<p>Abstract</p> <p>Background</p> <p>High risk type human papilloma viruses (HR-HPV) induce carcinomas of the uterine cervix by expressing viral oncogenes E6 and E7. Oncogene E7 of HR-HPV disrupts the pRb/E2F interaction, which negatively regulates the S phase entry. Ex...

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Main Authors: Frank Georgy A, Andreeva Yulia Y, Katargin Alexey N, Volgareva Galina M, Zavalishina Larisa E, Golovina Daria A, Ivanova Tatiana A, Kisseljov Fjodor L, Kisseljova Natalia P
Format: Article
Language:English
Published: BMC 2007-03-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/7/47

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http://www.biomedcentral.com/1471-2407/7/47

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