Identification of Proteins Differentially Expressed in the Striatum by Melatonin in a Middle Cerebral Artery Occlusion Rat Model—a Proteomic and in silico Approach

Identification of Proteins Differentially Expressed in the Striatum by Melatonin in a Middle Cerebral Artery Occlusion Rat Model—a Proteomic and in silico Approach

Ischemic stroke is characterized by permanent or transient obstruction of blood flow, which initiates a cascading pathological process, starting from acute ATP loss to subsequent membrane depolarization, glutamate excitotoxicity, and calcium overload. Melatonin is a potent antioxidant that exerts pr...

Full description

Bibliographic Details
Main Authors: Fawad Ali Shah, Amir Zeb, Tahir Ali, Tahir Muhammad, Muhammad Faheem, Sayed Ibrar Alam, Kamran Saeed, Phil-Ok Koh, Keun Woo Lee, Myeong Ok Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Neuroscience
Subjects:
melatonin
striatum
ischemic stroke
docking
neuroprotection
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00888/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00888/full

Similar Items