Heteronemin Induces Anti-Proliferation in Cholangiocarcinoma Cells via Inhibiting TGF-β Pathway

Heteronemin Induces Anti-Proliferation in Cholangiocarcinoma Cells via Inhibiting TGF-β Pathway

A marine sesterterpenoid-type natural product, heteronemin, retains anticancer effects. In the current study, we investigate the antitumor mechanism of heteronemin in cholangiocarcinoma cells and further explore its molecular targets. Initially, heteronemin exhibited potent cytotoxic effects against...

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Bibliographic Details
Main Authors: Hung-Yun Lin, Shu-Leei Tey, Yih Ho, Yung-Tang Chin, Kuan Wang, Jacqueline Whang-Peng, Ya-Jung Shih, Yi-Ru Chen, Yung-Ning Yang, Yu-Cheng Chen, Yi-Chang Liu, Heng-Yuan Tang, Yu-Chen SH Yang
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Marine Drugs
Subjects:
heteronemin
cholangiocarcinoma
TGF-β pathway
Online Access:https://www.mdpi.com/1660-3397/16/12/489

Internet

https://www.mdpi.com/1660-3397/16/12/489

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