Knockdown of ANGPTL2 promotes left ventricular systolic dysfunction by upregulation of NOX4 in mice

Knockdown of ANGPTL2 promotes left ventricular systolic dysfunction by upregulation of NOX4 in mice

Background: Angiopoietin-like 2 (ANGPTL2) is a pro-inflammatory and pro-oxidant circulating protein that predicts and promotes chronic inflammatory diseases such as atherosclerosis in humans. Transgenic murine models demonstrated the deleterious role of ANGPTL2 in vascular diseases, while deletion o...

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Bibliographic Details
Main Authors: Pauline Labbé, Cécile Martel, Yan-Fen Shi, Augusto Montezano, Ying He, Marc-Antoine Gillis, Marie-Ève Higgins, Louis Villeneuve, Rhian Touyz, Jean-Claude Tardif, Nathalie Thorin-Trescases, Eric Thorin
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Physiology
Subjects:
ANGPTL2
NOX4
heart homeostasis
oxidative stress
left ventricular systolic dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2024.1320065/full

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https://www.frontiersin.org/articles/10.3389/fphys.2024.1320065/full

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