Comparing the Phenylalanine/Tyrosine Pathway and Related Factors between Keratopathy and No-Keratopathy Groups as Well as between Genders in Alkaptonuria during Nitisinone Treatment

Comparing the Phenylalanine/Tyrosine Pathway and Related Factors between Keratopathy and No-Keratopathy Groups as Well as between Genders in Alkaptonuria during Nitisinone Treatment

Nitisinone (NIT) causes tyrosinaemia and corneal keratopathy (KP), especially in men. However, the adaptation within the phenylalanine (PHE)/tyrosine (TYR) catabolic pathway during KP is not understood. The objective of this study is to assess potential differences in the PHE/TYR pathway during KP a...

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Bibliographic Details
Main Authors: Lakshminarayan R. Ranganath, Anna M. Milan, Andrew T. Hughes, Andrew S. Davison, Milad Khedr, Richard Imrich, Mattias Rudebeck, Birgitta Olsson, Brendan P. Norman, George Bou-Gharios, James A. Gallagher
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Metabolites
Subjects:
sex
keratopathy
alkaptonuria
homogentisic acid
hydroxyphenylpyruvate
hydroxyphenyllactate
Online Access:https://www.mdpi.com/2218-1989/12/8/772

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https://www.mdpi.com/2218-1989/12/8/772

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