Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure.

Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure.

Hepatitis B virus (HBV) replicates its 3 kb DNA genome through capsid-internal reverse transcription, initiated by assembly of 120 core protein (HBc) dimers around a complex of viral pregenomic (pg) RNA and polymerase. Following synthesis of relaxed circular (RC) DNA capsids can be enveloped and sec...

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Bibliographic Details
Main Authors: Julia Heger-Stevic, Peter Zimmermann, Lauriane Lecoq, Bettina Böttcher, Michael Nassal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007488

Internet

https://doi.org/10.1371/journal.ppat.1007488

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