Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma

Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma

Abstract Background Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPGs), are a fatal form of brain cancer. These tumors often carry a driver mutation on histone H3 converting lysine 27 to methionine (H3K27M). DMG-H3K27M are characterized by altered metabolism and resis...

Full description

Bibliographic Details
Main Authors: Erik R. Peterson, Peter Sajjakulnukit, Andrew J. Scott, Caleb Heaslip, Anthony Andren, Kari Wilder-Romans, Weihua Zhou, Sravya Palavalasa, Navyateja Korimerla, Angelica Lin, Alexandra O’Brien, Ayesha Kothari, Zitong Zhao, Li Zhang, Meredith A. Morgan, Sriram Venneti, Carl Koschmann, Nada Jabado, Costas A. Lyssiotis, Maria G. Castro, Daniel R. Wahl
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Cancer & Metabolism
Subjects:
Diffuse midline glioma
H3K27M
Radiation therapy resistance
Purine metabolism
Online Access:https://doi.org/10.1186/s40170-024-00341-7

Internet

https://doi.org/10.1186/s40170-024-00341-7

Similar Items