Nevirapine Increases Sodium/Iodide Symporter-Mediated Radioiodide Uptake by Activation of TSHR/cAMP/CREB/PAX8 Signaling Pathway in Dedifferentiated Thyroid Cancer

Nevirapine Increases Sodium/Iodide Symporter-Mediated Radioiodide Uptake by Activation of TSHR/cAMP/CREB/PAX8 Signaling Pathway in Dedifferentiated Thyroid Cancer

Nevirapine has been proved to be effective in inducing re-differentiation and suppressing tumor growth in several tumor cells. This study aims to investigate the therapeutic potential of nevirapine in dedifferentiated thyroid cancer (DeTC), which refractory to radioiodine treatment and the underlyin...

Full description

Bibliographic Details
Main Authors: Hongxia Shang, Junyu Zhao, Jinming Yao, Huanjun Wang, Jianjun Dong, Lin Liao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Oncology
Subjects:
nevirapine
radioiodide uptake
sodium/iodide symporter
TSHR/cAMP/CREB/PAX8 signaling pathway
dedifferentiated thyroid cancer
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00404/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00404/full

Similar Items