Nevirapine Increases Sodium/Iodide Symporter-Mediated Radioiodide Uptake by Activation of TSHR/cAMP/CREB/PAX8 Signaling Pathway in Dedifferentiated Thyroid Cancer
Nevirapine has been proved to be effective in inducing re-differentiation and suppressing tumor growth in several tumor cells. This study aims to investigate the therapeutic potential of nevirapine in dedifferentiated thyroid cancer (DeTC), which refractory to radioiodine treatment and the underlyin...
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| Format: | Article |
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Frontiers Media S.A.
2020-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.00404/full |
| _version_ | 1818934464524320768 |
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| author | Hongxia Shang Junyu Zhao Junyu Zhao Jinming Yao Huanjun Wang Jianjun Dong Lin Liao Lin Liao |
| author_facet | Hongxia Shang Junyu Zhao Junyu Zhao Jinming Yao Huanjun Wang Jianjun Dong Lin Liao Lin Liao |
| author_sort | Hongxia Shang |
| collection | DOAJ |
| description | Nevirapine has been proved to be effective in inducing re-differentiation and suppressing tumor growth in several tumor cells. This study aims to investigate the therapeutic potential of nevirapine in dedifferentiated thyroid cancer (DeTC), which refractory to radioiodine treatment and the underlying mechanisms. The results indicated that nevirapine significantly inhibited the proliferation and increased the expressions of thyroid differentiation-related genes, thyroid stimulating hormone receptor (TSHR), sodium/iodide symporter (NIS), thyroid peroxidase (TPO), and transcriptional factor paired box 8 (PAX8) in dedifferentiated thyroid cancer cells (WRO 82-1 and dFTC-133). Furthermore, nevirapine also enhanced radioiodide uptake significantly both in vitro and in vivo, and inhibited the growth of xenograft tumors. Nevirapine might improve radioiodine sensitivity via the activation of TSHR/cAMP/CREB/PAX8 signaling pathway. This study demonstrates that nevirapine could be potentially used to improve radioiodine therapeutic efficacy in dedifferentiated thyroid cancer patients. |
| first_indexed | 2024-12-20T05:04:42Z |
| format | Article |
| id | doaj.art-1952a53674414b549204b6c3670a1941 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-20T05:04:42Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj.art-1952a53674414b549204b6c3670a19412022-12-21T19:52:26ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-03-011010.3389/fonc.2020.00404481823Nevirapine Increases Sodium/Iodide Symporter-Mediated Radioiodide Uptake by Activation of TSHR/cAMP/CREB/PAX8 Signaling Pathway in Dedifferentiated Thyroid CancerHongxia Shang0Junyu Zhao1Junyu Zhao2Jinming Yao3Huanjun Wang4Jianjun Dong5Lin Liao6Lin Liao7Department of Endocrinology and Metabology, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Ji-nan, ChinaDepartment of Endocrinology and Metabology, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Ji-nan, ChinaDepartment of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University, Ji-nan, ChinaDepartment of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University, Ji-nan, ChinaDepartment of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University, Ji-nan, ChinaDepartment of Endocrinology and Metabology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Ji-nan, ChinaDepartment of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University, Ji-nan, ChinaDepartment of Endocrinology and Metabology, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Ji-nan, ChinaNevirapine has been proved to be effective in inducing re-differentiation and suppressing tumor growth in several tumor cells. This study aims to investigate the therapeutic potential of nevirapine in dedifferentiated thyroid cancer (DeTC), which refractory to radioiodine treatment and the underlying mechanisms. The results indicated that nevirapine significantly inhibited the proliferation and increased the expressions of thyroid differentiation-related genes, thyroid stimulating hormone receptor (TSHR), sodium/iodide symporter (NIS), thyroid peroxidase (TPO), and transcriptional factor paired box 8 (PAX8) in dedifferentiated thyroid cancer cells (WRO 82-1 and dFTC-133). Furthermore, nevirapine also enhanced radioiodide uptake significantly both in vitro and in vivo, and inhibited the growth of xenograft tumors. Nevirapine might improve radioiodine sensitivity via the activation of TSHR/cAMP/CREB/PAX8 signaling pathway. This study demonstrates that nevirapine could be potentially used to improve radioiodine therapeutic efficacy in dedifferentiated thyroid cancer patients.https://www.frontiersin.org/article/10.3389/fonc.2020.00404/fullnevirapineradioiodide uptakesodium/iodide symporterTSHR/cAMP/CREB/PAX8 signaling pathwaydedifferentiated thyroid cancer |
| spellingShingle | Hongxia Shang Junyu Zhao Junyu Zhao Jinming Yao Huanjun Wang Jianjun Dong Lin Liao Lin Liao Nevirapine Increases Sodium/Iodide Symporter-Mediated Radioiodide Uptake by Activation of TSHR/cAMP/CREB/PAX8 Signaling Pathway in Dedifferentiated Thyroid Cancer Frontiers in Oncology nevirapine radioiodide uptake sodium/iodide symporter TSHR/cAMP/CREB/PAX8 signaling pathway dedifferentiated thyroid cancer |
| title | Nevirapine Increases Sodium/Iodide Symporter-Mediated Radioiodide Uptake by Activation of TSHR/cAMP/CREB/PAX8 Signaling Pathway in Dedifferentiated Thyroid Cancer |
| title_full | Nevirapine Increases Sodium/Iodide Symporter-Mediated Radioiodide Uptake by Activation of TSHR/cAMP/CREB/PAX8 Signaling Pathway in Dedifferentiated Thyroid Cancer |
| title_fullStr | Nevirapine Increases Sodium/Iodide Symporter-Mediated Radioiodide Uptake by Activation of TSHR/cAMP/CREB/PAX8 Signaling Pathway in Dedifferentiated Thyroid Cancer |
| title_full_unstemmed | Nevirapine Increases Sodium/Iodide Symporter-Mediated Radioiodide Uptake by Activation of TSHR/cAMP/CREB/PAX8 Signaling Pathway in Dedifferentiated Thyroid Cancer |
| title_short | Nevirapine Increases Sodium/Iodide Symporter-Mediated Radioiodide Uptake by Activation of TSHR/cAMP/CREB/PAX8 Signaling Pathway in Dedifferentiated Thyroid Cancer |
| title_sort | nevirapine increases sodium iodide symporter mediated radioiodide uptake by activation of tshr camp creb pax8 signaling pathway in dedifferentiated thyroid cancer |
| topic | nevirapine radioiodide uptake sodium/iodide symporter TSHR/cAMP/CREB/PAX8 signaling pathway dedifferentiated thyroid cancer |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.00404/full |
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