Increased Endocytosis of Cadmium-Metallothionein through the 24p3 Receptor in an In Vivo Model with Reduced Proximal Tubular Activity

Increased Endocytosis of Cadmium-Metallothionein through the 24p3 Receptor in an In Vivo Model with Reduced Proximal Tubular Activity

Background: The proximal tubule (PT) is the major target of cadmium (Cd<sup>2+</sup>) nephrotoxicity. Current dogma postulates that Cd<sup>2+</sup> complexed to metallothionein (MT) (CdMT) is taken up through receptor-mediated endocytosis (RME) via the PT receptor megalin:cub...

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Bibliographic Details
Main Authors: Itzel Pamela Zavala-Guevara, Manolo Sibael Ortega-Romero, Juana Narváez-Morales, Tania Libertad Jacobo-Estrada, Wing-Kee Lee, Laura Arreola-Mendoza, Frank Thévenod, Olivier Christophe Barbier
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
cadmium nephrotoxicity
gentamicin-induced nephrotoxicity
metallothionein uptake
distal tubule
Online Access:https://www.mdpi.com/1422-0067/22/14/7262

Internet

https://www.mdpi.com/1422-0067/22/14/7262

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