A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy

A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy

Background: Metabolic-associated fatty liver disease (MAFLD) has risen as one of the leading etiologies for hepatocellular carcinoma (HCC). Oncogenes have been suggested to be responsible for the high risk of MAFLD-related HCC. We analyzed the impact of the proto-oncogene c-MYC in the development of...

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Main Authors: Feifei Guo, Olga Estévez-Vázquez, Raquel Benedé-Ubieto, Douglas Maya-Miles, Kang Zheng, Rocío Gallego-Durán, Ángela Rojas, Javier Ampuero, Manuel Romero-Gómez, Kaye Philip, Isioma U. Egbuniwe, Chaobo Chen, Jorge Simon, Teresa C. Delgado, María Luz Martínez-Chantar, Jie Sun, Johanna Reissing, Tony Bruns, Arantza Lamas-Paz, Manuel Gómez del Moral, Marius Maximilian Woitok, Javier Vaquero, José R. Regueiro, Christian Liedtke, Christian Trautwein, Rafael Bañares, Francisco Javier Cubero, Yulia A. Nevzorova
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cancers
Subjects:
metabolic-associated fatty liver disease (MAFLD)
c-myc
oncogene
tumorigenesis
metformin
Online Access:https://www.mdpi.com/2072-6694/14/1/192

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https://www.mdpi.com/2072-6694/14/1/192

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