Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer’s disease

Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer’s disease

Abstract Defective amyloid-β (Aβ) clearance from the brain is a major contributing factor to the pathophysiology of Alzheimer’s disease (AD). Aβ clearance is mediated by macrophages, enzymatic degradation, perivascular drainage along the vascular basement membrane (VBM) and transcytosis across the b...

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Bibliographic Details
Main Authors: Xiao Zhang, Paul O’Callaghan, Honglian Li, Yingxia Tan, Ganlin Zhang, Uri Barash, Xiaomin Wang, Lars Lannfelt, Israel Vlodavsky, Ulf Lindahl, Jin-Ping Li
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Acta Neuropathologica Communications
Subjects:
Perivascular drainage
Heparan sulfate
Heparanase
Amyloid-β
Clearance
Aging
Online Access:https://doi.org/10.1186/s40478-021-01182-x

Internet

https://doi.org/10.1186/s40478-021-01182-x

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