The Role of Insulin/IGF-1/PI3K/Akt/GSK3β Signaling in Parkinson's Disease Dementia

The Role of Insulin/IGF-1/PI3K/Akt/GSK3β Signaling in Parkinson's Disease Dementia

Dementia, a condition that frequently afflicts patients in advanced stages of Parkinson's disease (PD), results in decreased quality of life and survival time. Nevertheless, the pathological mechanisms underlying Parkinson's disease dementia (PDD) are not completely understood. The symptom...

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Bibliographic Details
Main Authors: Liying Yang, Hongyan Wang, Lijun Liu, Anmu Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Neuroscience
Subjects:
Parkinson's disease dementia (PDD)
insulin
Insulin-like growth factor (IGF-I)
phosphoinositide 3 kinase (PI3k)
Akt
Glycogen synthase kinase β (GSK3β)
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2018.00073/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2018.00073/full

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