Preclinical evaluation and reverse phase protein Array-based profiling of PI3K and MEK inhibitors in endometrial carcinoma in vitro

Preclinical evaluation and reverse phase protein Array-based profiling of PI3K and MEK inhibitors in endometrial carcinoma in vitro

Abstract Background The phosphoinositide-3-kinase (PI3K) pathway is the most commonly activated pathway in cancers due to mutations at multiple nodes and loss of PTEN. Furthermore, in endometrial cancer (EC), PI3K and RAS/RAF/MEK/MAPK (RAS/MAPK herein) pathway mutations frequently co-exist. We exami...

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Bibliographic Details
Main Authors: Ozlem Aslan, Mattia Cremona, Clare Morgan, Lydia W. Cheung, Gordon B. Mills, Bryan T. Hennessy
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Cancer
Subjects:
Endometrial cancer
Biomarkers
PTEN loss
PIK3CA
KRAS
PI3K inhibitor
Online Access:http://link.springer.com/article/10.1186/s12885-018-4035-0

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http://link.springer.com/article/10.1186/s12885-018-4035-0

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