Differences of Uric Acid Transporters Carrying Extracellular Vesicles in the Urine from Uric Acid and Calcium Stone Formers and Non-Stone Formers

Differences of Uric Acid Transporters Carrying Extracellular Vesicles in the Urine from Uric Acid and Calcium Stone Formers and Non-Stone Formers

Background: Low urine pH and volume are established risk factors for uric acid (UA) stone disease (UASD). Renal tubular epithelial cells exposed to an acidic pH and/or UA crystals can shed extracellular vesicles (EVs) into the tubular fluid, and these EVs may be a pathogenic biomarker of UASD. Metho...

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Bibliographic Details
Main Authors: Zhijian Lin, Muthuvel Jayachandran, Zejfa Haskic, Sanjay Kumar, John C. Lieske
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
urine pH
urinary vesicles
renal epithelial cells
nephrolithiasis
aciduria
Online Access:https://www.mdpi.com/1422-0067/23/17/10010

Internet

https://www.mdpi.com/1422-0067/23/17/10010

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