Effects of Normobaric Hypoxia and Adrenergic Blockade over 72 h on Cardiac Function in Rats

Effects of Normobaric Hypoxia and Adrenergic Blockade over 72 h on Cardiac Function in Rats

In rats, acute normobaric hypoxia depressed left ventricular (LV) inotropic function. After 24 h of hypoxic exposure, a slight recovery of LV function occurred. We speculated that prolonged hypoxia (72 h) would induce acclimatization and, hence, recovery of LV function. Moreover, we investigated bio...

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Bibliographic Details
Main Authors: Elias Neubert, Beate Rassler, Annekathrin Hoschke, Coralie Raffort, Aida Salameh
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
normobaric hypoxia
adrenergic blockade
cardiac function
hypoxia-inducible factor-1α
nitrotyrosine
apoptosis
Online Access:https://www.mdpi.com/1422-0067/24/14/11417

Internet

https://www.mdpi.com/1422-0067/24/14/11417

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