Microbial Fermentation Enhances the Effect of Black Tea on Hyperlipidemia by Mediating Bile Acid Metabolism and Remodeling Intestinal Microbes
Black tea (BT), the most consumed tea worldwide, can alleviate hyperlipidemia which is a serious threat to human health. However, the quality of summer BT is poor. It was improved by microbial fermentation in a previous study, but whether it affects hypolipidemic activity is unknown. Therefore, we c...
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| Format: | Article |
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MDPI AG
2024-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/7/998 |
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| author | Lingli Sun Lianghua Wen Qiuhua Li Ruohong Chen Shuai Wen Xingfei Lai Zhaoxiang Lai Junxi Cao Zhenbiao Zhang Mengjiao Hao Fanrong Cao Shili Sun |
| author_facet | Lingli Sun Lianghua Wen Qiuhua Li Ruohong Chen Shuai Wen Xingfei Lai Zhaoxiang Lai Junxi Cao Zhenbiao Zhang Mengjiao Hao Fanrong Cao Shili Sun |
| author_sort | Lingli Sun |
| collection | DOAJ |
| description | Black tea (BT), the most consumed tea worldwide, can alleviate hyperlipidemia which is a serious threat to human health. However, the quality of summer BT is poor. It was improved by microbial fermentation in a previous study, but whether it affects hypolipidemic activity is unknown. Therefore, we compared the hypolipidemic activity of BT and microbially fermented black tea (EFT). The results demonstrated that BT inhibited weight gain and improved lipid and total bile acid (TBA) levels, and microbial fermentation reinforced this activity. Mechanistically, both BT and EFT mediate bile acid circulation to relieve hyperlipidemia. In addition, BT and EFT improve dyslipidemia by modifying the gut microbiota. Specifically, the increase in <i>Lactobacillus johnsonii</i> by BT, and the increase in <i>Mucispirillum</i> and <i>Colidextribacter</i> by EFT may also be potential causes for alleviation of hyperlipidemia. In summary, we demonstrated that microbial fermentation strengthened the hypolipidemic activity of BT and increased the added value of BT. |
| first_indexed | 2024-04-24T10:37:36Z |
| format | Article |
| id | doaj.art-196ee70c2fbb417bbc37b6909b939959 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-04-24T10:37:36Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-196ee70c2fbb417bbc37b6909b9399592024-04-12T13:24:19ZengMDPI AGNutrients2072-66432024-03-0116799810.3390/nu16070998Microbial Fermentation Enhances the Effect of Black Tea on Hyperlipidemia by Mediating Bile Acid Metabolism and Remodeling Intestinal MicrobesLingli Sun0Lianghua Wen1Qiuhua Li2Ruohong Chen3Shuai Wen4Xingfei Lai5Zhaoxiang Lai6Junxi Cao7Zhenbiao Zhang8Mengjiao Hao9Fanrong Cao10Shili Sun11Tea Research Institute, Guangdong Provincial Key Laboratory of Tea Plant Resources Innovation and Utilization, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, ChinaCollege of Horticulture, South China Agricultural University, Guangzhou 510000, ChinaTea Research Institute, Guangdong Provincial Key Laboratory of Tea Plant Resources Innovation and Utilization, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, ChinaTea Research Institute, Guangdong Provincial Key Laboratory of Tea Plant Resources Innovation and Utilization, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, ChinaTea Research Institute, Guangdong Provincial Key Laboratory of Tea Plant Resources Innovation and Utilization, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, ChinaTea Research Institute, Guangdong Provincial Key Laboratory of Tea Plant Resources Innovation and Utilization, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, ChinaTea Research Institute, Guangdong Provincial Key Laboratory of Tea Plant Resources Innovation and Utilization, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, ChinaTea Research Institute, Guangdong Provincial Key Laboratory of Tea Plant Resources Innovation and Utilization, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, ChinaTea Research Institute, Guangdong Provincial Key Laboratory of Tea Plant Resources Innovation and Utilization, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, ChinaTea Research Institute, Guangdong Provincial Key Laboratory of Tea Plant Resources Innovation and Utilization, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, ChinaCollege of Horticulture, South China Agricultural University, Guangzhou 510000, ChinaTea Research Institute, Guangdong Provincial Key Laboratory of Tea Plant Resources Innovation and Utilization, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, ChinaBlack tea (BT), the most consumed tea worldwide, can alleviate hyperlipidemia which is a serious threat to human health. However, the quality of summer BT is poor. It was improved by microbial fermentation in a previous study, but whether it affects hypolipidemic activity is unknown. Therefore, we compared the hypolipidemic activity of BT and microbially fermented black tea (EFT). The results demonstrated that BT inhibited weight gain and improved lipid and total bile acid (TBA) levels, and microbial fermentation reinforced this activity. Mechanistically, both BT and EFT mediate bile acid circulation to relieve hyperlipidemia. In addition, BT and EFT improve dyslipidemia by modifying the gut microbiota. Specifically, the increase in <i>Lactobacillus johnsonii</i> by BT, and the increase in <i>Mucispirillum</i> and <i>Colidextribacter</i> by EFT may also be potential causes for alleviation of hyperlipidemia. In summary, we demonstrated that microbial fermentation strengthened the hypolipidemic activity of BT and increased the added value of BT.https://www.mdpi.com/2072-6643/16/7/998microbial fermented black teahyperlipidemiabile acidgut microbes |
| spellingShingle | Lingli Sun Lianghua Wen Qiuhua Li Ruohong Chen Shuai Wen Xingfei Lai Zhaoxiang Lai Junxi Cao Zhenbiao Zhang Mengjiao Hao Fanrong Cao Shili Sun Microbial Fermentation Enhances the Effect of Black Tea on Hyperlipidemia by Mediating Bile Acid Metabolism and Remodeling Intestinal Microbes Nutrients microbial fermented black tea hyperlipidemia bile acid gut microbes |
| title | Microbial Fermentation Enhances the Effect of Black Tea on Hyperlipidemia by Mediating Bile Acid Metabolism and Remodeling Intestinal Microbes |
| title_full | Microbial Fermentation Enhances the Effect of Black Tea on Hyperlipidemia by Mediating Bile Acid Metabolism and Remodeling Intestinal Microbes |
| title_fullStr | Microbial Fermentation Enhances the Effect of Black Tea on Hyperlipidemia by Mediating Bile Acid Metabolism and Remodeling Intestinal Microbes |
| title_full_unstemmed | Microbial Fermentation Enhances the Effect of Black Tea on Hyperlipidemia by Mediating Bile Acid Metabolism and Remodeling Intestinal Microbes |
| title_short | Microbial Fermentation Enhances the Effect of Black Tea on Hyperlipidemia by Mediating Bile Acid Metabolism and Remodeling Intestinal Microbes |
| title_sort | microbial fermentation enhances the effect of black tea on hyperlipidemia by mediating bile acid metabolism and remodeling intestinal microbes |
| topic | microbial fermented black tea hyperlipidemia bile acid gut microbes |
| url | https://www.mdpi.com/2072-6643/16/7/998 |
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